Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg 69120, Germany. Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg 69120, Germany. Department of Human Molecular Genetics, University of Heidelberg, Heidelberg 69120, Germany. Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio 48160, Spain. Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm 17177, Sweden. Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg 69120, Germany. Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders, KU Leuven, Leuven 3000, Belgium. Department of General Internal Medicine and Psychosomatics, Internal Medicine II, University Hospital Heidelberg, Heidelberg 69120, Germany. Department of Gastroenterology, Infectious Diseases and Intoxications, University of Heidelberg, Heidelberg 69120, Germany. Department of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg 69120, Germany. Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham NG7 2QL, United Kingdom. Helios Klinikum Rottweil, Rottweil 78628, Germany. Department of Medicine, Institute of Neurogastroenterology (H.M.), Martin-Luther-Hospital, Belin 14193, Germany. Israelitisches Krankenhaus in Hamburg, Hamburg 22297, Germany. Internal Medicine II, Helios Klinikum Krefeld, Krefeld 47805, Germany. Israelitisches Krankenhaus Hamburg, Hamburg 22297, Ghana. Krankenhaus Vilsbiburg, Vilsbiburg 84137, Germany. Division of Microbiome and Cancer, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. Department of Psychiatry and Neurobehavioral Science, University College Cork, Cork T23, Ireland. Medicine in Digestive Disorders, Department of Medicine, Lynda K. and David M. Underwood Center for Digestive Disorders, Houston Methodist, Houston, TX 77030, United States. Division of Gastroenterology, Washington University School of Medicine, Department of Psychiatry, School of Medicine, John Cochran Veteran Affairs Medical Center, St. Louis, MO 63110, United States. Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg SE-41685, Sweden. Cognitive and Affective Neuroscience Lab, Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03748, United States. Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg, Heidelberg 69120, Germany.